Asthma is a condition when the airway of an individual narrows, produces extra mucus and swell, this caused difficulty in breathing.
Currently there is no cure for asthma but it can be controlled.
The new discovery will help to develop new treatment in the next five years.
Researchers found the main cause of asthma and discovered that overactive calcium sensing receptor or CaSR reacts to environmental triggers like allergens, car fumes and smoke, cigarette smoke, inflaming and narrowing the airway which is causing symptoms of asthma.
Daniela Riccardi, a researcher from Cardiff University, described the findings as “completely unexpected.”
Riccardi said, “I previously worked on investigating the role of this particular sensor in other conditions, such as osteoporosis, before we found that this sensor was present in the airways, the triggers release chemicals that activate a sensor in the airways — if we can block these sensors we can prevent all the symptoms. We knew these chemicals were released during asthma attacks, but didn’t know how they worked and didn’t have the drug target that could prevent all of these symptoms. Now we know exactly how they work, we can prevent all of these symptoms.”
Researchers found CaSR causes asthma, and they said this can help them is finding a new treatment.
The study found that the class of drugs called calcilytics affects CaSR and it can reverse the reactions that cause asthmatic symptoms.
Calcilytics were developed as a treatment for osteoporosis, but they were found ineffective for the the treatment.
Researchers hope that asthmatics would never have to experience asthma symptoms and they would try to replace inhalers.
Riccardi said, “If we can prove that calcilytics are safe when administered directly to the lung in people, then in five years we could be in a position to treat patients and potentially stop asthma from happening in the first place.”
Clinical trials to test calcilytics in asthma patients have been designed, but researchers are waiting for funding.
Within two years human trail will begin.